Are you really that stupid to listen to all these people? A lot of these guys have no idea what they are talking about. Mixing most common over the counter painkillers and alcohol aren't that bad for you. Ibuprofen isn't too bad for example. However, I would not try drinking Tylenol-3's and Alcohol. Tylenol-3's have codeine in them which can cause serious complications with alcohol. Just because it says to only take 2 or whatever every 8 hours DOES NOT meant it is out of your system. It can be in there longer. If you are worried about it, don't do it. Personally I would never mix hardcore painkillers like codeine or vicodin with alcohol. Not worth the liver damage.