No one can win best guitarist 'hands down'.  What is this, technique, speed, composition, soloing, what...?  You can't say in general... But here are a few :
-Soloing: This, I challenge anyone to say it isn't Jimi.  Of course, you've probably seen a 'video' of someone doing something flashier than Jimi, but he would improv the hell out of that guy so bad...
-Riffs: Probably Jimmy Page.  He's also a god at soloing, but he falls in an entirely different category then Jimi Hendrix.
-Melodic: Pete Townshend.  I've never seen anyone mention the Who once on NS, but just for the overall composition of songs, I'd say Pete is the best.
-Real overall best guitarist: Probably some obscure classical guitar player that was or is in some lost country somewhere.  No one will ever know.  You can't define a BEST overall guitarist, just your personal favorites.  But please, Kurt Cobain?
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