* Georges P. Vanier (1906) - Governor General of Canada. His son Jean Vanier, the founder of L'Arche, also attended Loyola.
* Charles Gavan "Chubby" Power (1906) - Senator; Minister of National Defence for Air
* John Kearney (1916) - Justice, The Exchequer Court of Canada; Minister to Ireland and to India
* William Joseph Mackey S.J. (1932) - Responsible for establishing the modern education system in Bhutan
* Warren Allmand (1948) - Solicitor-General, Minister of Indian Affairs, and Minister of Consumer and Corporate Affairs in the governments of Prime Minister Trudeau
* Richard Monette (1963) - Actor, artistic director of the Stratford Festival of Canada from 1994 to 2007
* Mark Starowicz (1964) - Writer, historian, producer, journalist
* Jim Flaherty (1966) - Minister of Finance from 2006 to present
* Sam Roberts (1992) (along with two of his bandmates, one of his record producers, and one of his video producers) also attended Loyola High School and have recently returned to perform for the 2005 Festival of the Arts
* Don Ferguson and Roger Abbott of Royal Canadian Air Farce were both students as well, and met at the School