Worth pointing out also that the Buffalo game was a road game for BOTH teams as it was played in Toronto.
Personally, road and home records aside, I think both teams are coming in hot and have a ton of confidence, I think RGIII is still a bit gimped, I think both offenses are pretty similar (strong running games and mobile quarterbacks give multiple options on the ground and both guys have good arms and people to throw to), and I think Seattle's defense is way, way better than Washington's. Lynch can run through the 'Skins D. I am not sure Morris will have as much success against the Hawks D. That, for me, is the difference. Seattle is simply a more complete and as a result an overall better football team. They should win, even without the 12th man giving them an extra two or three delay of game penalties.
I won't be shocked if they don't though, it's pretty close and who knows, maybe they take a day off.