first off, how many people are in your league? that is going to dictate to some degree who you can pick when. for your first two picks, try to get the top point producers. it could be a top RB like LT, ALexander, or Larry Johnson, or it could be a top QB like Manning, Palmer, or Hasselbeck. either way try to get your top RB and QB in the first and second rounds. after that, just compare what is available and what you need. also don't fall in love with players, and look for sleeper picks in the later rounds.