I am a lefty but learned to play righty because when I went to buy my first guitar the guy said "look around this entire store (100's of guitars), three of these are lefty, and they're more expensive". Also you can't play random guitars you find.
However, learning to play Jimi Hendrix style is dope. You don't limit yourself at all that way. If I had to do it all over again I might learn that way. But I've tried and its just too hard.
Also, random trivia, Stevie Ray Vaughan idolized Jimi Hendrix so much he had the neck on his guitar changed to make it look like he was playing it upside down. I think his signiture guitar might be like that, so if you bought it to play upside down it would look normal.