Cannabis as an Antioxidant: What Studies Say
Numerous studies have found that the cannabinoids in cannabis – specifically tetrahydrocannabinol (THC) and cannabidiol (CBD) – display potent antioxidant properties in a variety of pre-clinical applications.
One of the first studies to document these effects was a study published in 1998, which found that cannabinoids could protect neurons from exposure to toxic levels of glutamate – a neurotransmitter that plays a role in a number of neurodegenerative disorders. The study compared cannabinoids head-to-head with antioxidant vitamins C and E and found cannabidiol to be 30-50% more effective than either of the vitamins. A follow-up trial published in 2000 showed similar results using animal models instead of cell cultures.
Subsequent pre-clinical trials have confirmed the therapeutic potential of cannabidiol’s antioxidant properties in a variety of neurodegenerative and inflammatory disease models, including collagen-induced arthritis, infarction, Alzheimer’s disease, diabetes, myocardial ischemia and atherosclerosis. Researchers have focused on cannabidiol because of its affinity towards CB2 receptors and its lack of psychoactive effects, which occur through activation of CB1 receptors instead.
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